Focusing on his culture and the changing way of life of both urban and reservation Indians, along with the attendant socio-political issues, Jackson uses his work to educate society on the reality of contemporary Indian existence.

Jackson's work has been exhibited at the Smithsonian Institution, the International Center of Photography (New York), and the High Museum (Atlanta). His photography is represented in collections including the San Francisco Museum of Modern Art; the Jonson Gallery of the University of New Mexico; the Institute of American Indian Arts; the Museum of Contemporary Photography, Chicago; the Joslyn Art Museum, Nebraska; and the Savannah College of Art and Design.

In 2004, Jackson became the first Native American photographer to be represented in the collection of the National Library of Congress, when the Prints and Photographs Division acquired a number of his images. The artist is currently working on a photographic book of his work.